Shiying Li
Visiting scholar
Research interest
Drug assemblies and translational nanomedicine
Work Experience
2017-Present, Prof., School of Pharmaceutical Sciences, Guangzhou Medical University,
Education Background
Ph.D, Chemistry and Physics of Polymers, Wuhan University, 2014-2017
M.Sc., Chemistry and Physics of Polymers, Wuhan University, 2012-2014
B.Sc. Materials Chemistry, Wuhan University, 2008-2012
E-mail: lisy-sci@gzhmu.edu.cn
Publication
1. Zheng R R, Huang C Y, Zhou H Y, Zhao L X, Li Q Y, Chen G M, Zhao L P*, Li S Y*. Multi-synergistic chemotherapeutic drug assemblies to activate colorectal cancer immunotherapy by modulating the multilevel immunosuppressive characteristics. Aggregate 2024, DOI: 10.1002/agt2.610.
2. Yan M Y, Chen X Y, Liu Q Q, Yu B X, Cen Y, Zhang W, Liu Y B, Li X X, Chen Y, Wang T*, Li S Y*. Transferrin targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption. Acta Pharm. Sin B 2024, 10.1016/j.apsb.2024.05.030.
3. Zhao L P, Zheng R R, Rao X N, Huang C Y, Zhou H Y, Yu X Y, Jiang X Y, Li S Y*. Chemotherapies-enabled colorectal cancer immunotherapy of self-delivery nano-PROTACs by inhibiting tumor glycolysis and avoiding adaptive immune resistance. Adv. Sci. 2024, 11, 2309204.
4. Cen Y, Chen Y, Li X X, Chen X Y, Yu B X, Yan M Y, Li S Y*. Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for macrophage immunotherapy against metastatic breast cancer. Biomaterials 2024, 308, 122568.
5. Yu B X, Liu Y B, Chen X Y, Zhang W, Cen Y, Yan M Y, Liu Q Q, Li S Y*. Self assembled PD-L1 downregulator to boost photodynamic activated tumor immunotherapy through CDK5 inhibition. Small 2024, 2311507.
6. Liu Q Q, Chen X Y, Jiang Y, Yan M Y, Yu B X, Zhang W, Cen Y, Zhang J Y, Zhang J, Lei Q*, Li S Y*, Yang B*. Self-promoted targeting delivery of nanodrug through chemotherapeutic upregulation of CD47 for triple negative breast cancer therapy. Adv. Funct. Mater. 2024, 34, 2311677.
7. Li X T, Peng S Y, Feng S M, Bao T Y, Li S Z, Li S Y*. Recent progress in phage-based nanoplatform for tumor therapy. Small 2024, 20, 2307111.
8. Wei Y X, Chen Z X, Huang C Y, Cheng H*, Jiang X F*, Li S Y*. A breast cancer targeted photodynamic degrader to activate immunotherapy through EGFR degradation mediated PD-L1 downregulation. Chem. Eng. J. 2024, 488, 150822.
9. Zhang W, Yu B X, Chen X Y, Yan M Y, Liu Q Q, Liu Y B, Yang N, Cai H, Yan N, Kong R J, Cheng H*, Li S Y*, Chen A L*. Tumor homing chimeric peptide rhomboids to improve photodynamic performance by inhibiting therapy-upregulated cyclooxygenase-2. Small 2024, 2309882.
10. Huang C Y, Zhao L P, Rao X N, Zheng R R, Liu Z S, Cai H, Zhang W, Chen A L, Xu L, Li S Y*. Self assemblies of Chlorin e6 and BLZ945 to activate photodynamic immunotherapy through immunogenic tumor induction and tumor associated macrophage depletion. Adv. Healthc. Mater. 2024, 2304576.
11. Liu Y B, Chen X Y, Yu B X, Cen Y, Huang C Y, Yan M Y, Liu Q Q, Zhang W, Li S Y*, Tang Y Z*. Chimeric peptide engineered self-delivery nanomedicine for photodynamic triggered breast cancer immunotherapy by macrophage polarization. Small 2024, 2309994.
12. Chen X Y, Yan M Y, Liu Q Q, Yu B X, Cen Y, Li S Y*. Chimeric peptide engineered bio-regulator for metastatic tumor immunotherapy through macrophage polarization and phagocytosis restoration. ACS Nano 2023, 17, 16056-16068.
13. Zheng R R, Zhao L P, Huang C Y, Cheng H, Yang N, Chen Z X, Cai H, Zhang W, Kong R J, Li S Y*. Paraptosis inducer to effectively trigger immungenic cell death for metastatic tumor immunotherapy with IDO inhibition. ACS Nano 2023, 17, 9972-9986.
14. Zhao L P, Rao X N, Zheng R R, Huang C Y, Kong R J, Cheng H*, Li B*, Li S Y*. Carrier free nano-PROTACs to amplify photodynamic therapy induced DNA damage through BRD4 degradation. Nano Lett. 2023, 23, 6193-6201.
15. Zhao L P, Rao X N, Zheng R R, Huang C Y, Kong R J, Yu X Y*, Cheng H*, Li S Y*. Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication. J. Control. Release 2023, 357, 460-471.
16. Cen Y, Chen X Y, Liu Y B, Yu B X, Yan M Y, Yang N, Kong R J, Li S Y*, Ti H H*, Cheng H*. Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors. J. Control. Release 2023, 358, 654-666.
17. Zhao L P, Rao X N, Huang C Y, Zheng R R, Kong R J, Chen Z X, Yu X Y*, Cheng H*, Li S Y*. Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition. Biomaterials 2023, 293, 121952.
18. Chen A L, Yang N, Zhang W, Zheng R R, Yu R, Kong R J, Wang Y Q, Cheng H, Yu X Y, Li S Y*. Pyroptosis induction synergized with IDO inhibition of ternary biomedicine for photodynamic activated tumor immunotherapy. Chem. Eng. J. 2023, 478, 147465.
19. Li X T, Chen L, Huang M T, Zeng S T, Zeng J Y, Peng S Y, Wang Y Q, Cheng H*, Li S Y*. Innovative strategies for photodynamic therapy against hypoxic tumors. Asian J. Pharm. Sci. 2023, 18, 100775.
20. Zhong Y T, Cen Y, Xu L*, Li S Y*, Cheng H*. Recent progresses in carrier-free nanomedicine for tumor phototherapy. Adv. Health. Mater. 2023, 12, 2202307.
21. Zheng R R, Zhao L P, Yang N, Chen Z X, Kong R J, Huang C Y, Rao X N, Chen X*, Cheng H*, Li S Y*. Cascade immune activation of self delivery biomedicine for photodynamic immunotherapy against metastatic tumors. Small 2023, 19, 2205694.
22. Zhou X, Kong R J, Deng F A, Xie Y C, Huang J Q, Li Y M, Wu Y Y, Li S Y*, Cheng H*. Self-delivery photothermal converter for feedback enhanced tumor therapy by cascade inflammation inhibition. Chem. Eng. J. 2023, 453, 139887.
23. Zhao L P, Huang C Y, Zheng R R, Rao X N, Kong R J, Guan R T, Chen Z X, Yu X Y, Cheng H*, Li S Y*. Photodynamic amplified immune checkpoint-blockade therapy of self-delivery bioregulator via epigenetic reprogramming. Chem. Eng. J. 2023, 453, 139729.
24. Zhao L P, Zheng R R, Huang C Y, Rao X N, Yang N, Chen A L, Yu X Y*, Cheng H*, Li S Y*. Self-delivery ternary bioregulators for photodynamic amplified immunotherapy by tumor microenvironment reprogramming. ACS Nano 2022, 16, 1182-1197.
25. Chen X Y, Zheng R R, Zhao L P, Kong R J, Yang N, Liu Y B, Chen A L, Wang C*, Cheng H*, Li S Y*. Photodynamic therapy initiated immunotherapy of self-delivery re-educator by inducing immunogenic cell death and macrophage polarization. Chem. Eng. J. 2022, 435, 134783.
26. Deng F A, Yan M Y, Liu Y B, Wang R X, He H Q, Chen A L, Wang J J, Xu L, Cheng H*, Li S Y*. Self-delivery of metal-coordinated mitochondria protonophore uncoupler for O2-exhausting enhanced bioreductive therapy. Biomaterials 2022, 286, 121576.
27. Zheng R R, Liu Y B, Yu B X, Zhao L P, Yang N, Chen A L, Xu L, Cheng H*, Jiang X Y*, Li S Y*. Carrier free nanomedicine for synergistic cancer therapy by initiating apoptosis and paraptosis. J. Colloid. Interf. Sci. 2022, 622, 298-308.
28. Zhang W L, Chen H Q, Ding L Y, Gong J W, Zhang M R, Guo W Y, Xu P Y*, Li S Y*, Zhang Y L*. Trojan horse delivery of 4,4`-dimethoxychalcone for parkinsonian neuroprotection. Adv. Sci. 2021, 8, 2004555.
29. Zhao L P, Chen S Y, Zheng R R, Kong R J, Rao X N, Chen A L, Cheng H*, Zhang D W*, Li S Y*, Yu X Y*. Self-delivery nanomedicine for glutamine-starvation enhanced photodynamic tumor therapy. Adv. Health. Mater. 2021, 11, 202102038.
30. Fan G L, Deng F A, Zhou X, Liu L S, Huang J Q, Zhang D W, Sun Y X, Chen A L*, Cheng H*, Li S Y*. Plasma membrane targeted photodynamic O2 economizer for hypoxic tumor therapy. Biomaterials 2021, 273, 120854.
31. Li X Y, Deng F A, Zheng R R, Liu L S, Liu Y B, Kong R J, Chen A L, Yu X Y, Li S Y*, Cheng H*. Carrier free photodynamic synergists for oxidative damage amplified tumor therapy. Small 2021, 17, 2102470.
32. Zhao L P, Zheng R R, Liu L S, Chen X Y, Guan R T, Yang N, Chen A L, Yu X Y*, Cheng H*, Li S Y*. Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy. Biomaterials 2021, 275, 120970.
33. Zheng R R, Zhao L P, Chen X Y, Liu L S, Liu Y B, Chen X T, Wang C, Yu X Y, Cheng H*, Li S Y*. Metal-coordinated nanomedicine for combined tumor therapy by inducing paraptosis and apoptosis. J. Control. Release 2021, 336, 159-168.
34. Liu Y B, Deng F A, Zheng R R, Chen X Y, Zhao L P, Yu B X, Chen A L, Jiang X Y*, Cheng H*, Li S Y*. Self-delivery nanomedicine for vascular disruption-supplemented chemo-photodynamic tumor therapy. J. Colloid. Interf. Sci. 2021, 612, 562-571.
35. Yuan P, Deng F A, Liu Y B, Zheng R R, Rao X N, Qiu X Z, Zhang D W, Yu X Y, Cheng H*, Li S Y*. Mitochondria targeted O2 economizer to alleviate tumor hypoxia for enhanced photodynamic therapy. Adv. Health. Mater. 2021, 202100198.
36. Zhao L P, Zheng R R, Huang J Q, Chen X Y, Deng F A, Liu Y B, Huang C Y, Yu X Y*, Cheng H*, Li S Y*. Self-delivery photo-immune stimulators for photodynamic sensitized tumor immunotherapy. ACS Nano 2020, 14, 17100-17113.
37. Zhao L P, Zheng R R, Fan G L, Fan J H, Yuan P, Liu L S, Qiu X Z, Yu X Y*, Cheng H*, Li S Y*. Self-delivery nanomedicine for O2-economized photodynamic tumor therapy. Nano Lett. 2020, 20, 2062-2071.
38. Yuan P, Fan G L, Fan J H, Zhao L P, Liu L S, Deng F A, Jiang X Y, Hu A H, Yu X Y, Chen A L*, Cheng H*, Li S Y*. Tumor targeted self-synergistic nanoplatforms for aresnic sensitized photodynamic therapy. Acta Biomater. 2020, 117, 349-360.
39. Cheng H, Fan G L, Fan J H, Yuan P, Deng F A, Qiu X Z, Yu X Y, Li S Y*, Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy. Biomaterials 2019, 224, 119497.
40. Cheng H, Fan J H, Zhao L P, Fan G L, Zheng R R, Qiu X Z, Yu X Y*, Li S Y*, Zhang X Z. Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy. Biomaterials 2019, 211, 14-24.
41. Cheng H, Zheng R R, Fan G L, Fan J H, Zhao L P, Jiang X Y, Yang B, Yu X Y*, Li S Y*, Zhang X Z. Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy. Biomaterials 2019, 188, 1-11.
42. Cheng H*, X Y Jiang, Zheng R R, Zuo S J, Zhao L P, Fan G L, Xie B R, Yu X Y, Li S Y*，Zhang X Z. A biomimetic cascade nanoreactor for tumor targeted starvation therapy amplified chemotherapy. Biomaterials 2019, 195, 75-85.
43. Cheng H, Yuan P, Fan G L, Zhao L P, Zheng R R, Yang B, Qiu X Z, Yu X Y, Li S Y*, Zhang X Z. Chimeric peptide nanorods for plasma membrane and nuclear targeted photosensitizer delivery and enhanced photodynamic therapy. Appl. Mater. Today 2019, 16, 120-131.
44. Li S Y, Xie B R, Cheng H, Li C X, Zhang M K, Qiu W X, Liu W L, Wang X S, Zhang X Z*. A biomimetic theranostic O2-meter for cancer targeted photodynamic therapy and phosphorescence imaging. Biomaterials 2018, 1, 1-12.
45. Li S Y, Cheng H, Xie B R, Qiu W X, Zeng J Y, Li C X, Zhang L, Liu W L, Zhang X Z*. Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy. ACS Nano 2017, 11, 7006-7018.
46. Li S Y, Qiu W X, Cheng H, Gao F, Cao F Y, Zhang X Z*. A versatile plasma membrane engineered cell vehicle for contact cell enhanced photodynamic therapy. Adv. Funct. Mater. 2017, 27, 1604916.
47. Li S Y, Cheng H, Chen K W, Qiu W X, Zhang L, Wan S S, Zeng J Y, Zheng H R, Zhang X Z*. Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy. Biomaterials 2017, 142, 149-161.
48. Li S Y, Cheng H, Xie B R, Qiu W X, Song L L, Zhuo R X, Zhang X Z*. A ratiometric theranostic probe for tumor targeting therapy and self-therapeutic monitoring. Biomaterials 2016, 104, 297-309.
49. Li S Y, Liu L H, Rong L, Qiu W X, Jia H Z, Li B, Li F, Zhang X Z*. A dual-FRET-based versatile prodrug for real-time drug release monitoring and in situ therapeutic efficacy evaluation. Adv. Funct. Mater. 2015, 25, 7317-7326.
50. Li S Y, Cheng H, Qiu W X, Liu L H, Chen S, Hu Y, Xie B R, Li B, Zhang X Z*. Protease-activable cell-penetrating peptide-protoporphyrin conjugate for targeted photodynamic therapy in vivo. ACS Appl. Mater. Interfaces 2015, 7, 28319-28329.